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Copper peptide GHK-Cu is a naturally occurring tripeptide composed of glycyl-L-histidyl-L-lysine with a copper(II) ion. Extensively studied for its role in tissue remodeling, wound healing, and anti-inflammatory research applications.
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Absolutely. Contact your dedicated account manager or reach out to info@signalpeps.com with the product name and lot number. COAs are also available digitally through our AuthentiChain verification badge on each product page.
In-depth findings from peer-reviewed preclinical and clinical studies
GHK-Cu is a naturally occurring copper-binding tripeptide first isolated from human plasma in 1973, extensively studied for its regenerative, anti-inflammatory, and gene-modulating properties.
GHK-Cu stimulated synthesis of type I and type III collagen, increased elastin production, and enhanced extracellular matrix remodeling in fibroblast models. One study showed collagen production increased in 70% of treated subjects, outperforming vitamin C and retinoic acid creams.
International Journal of Molecular Sciences (2018)A 12-week double-blind facial cream study showed GHK-Cu increased skin density and thickness, reduced laxity, and improved clarity and wrinkle depth in women with signs of photoaging.
International Journal of Molecular Sciences (2018)GHK-Cu upregulated 1,942 genes and suppressed 762 genes in human fibroblasts — affecting 31.2% of the human genome, including pathways for DNA repair, antioxidant defense, and anti-inflammation.
International Journal of Molecular Sciences (2018)GHK-Cu attracted immune and endothelial cells to injury sites, stimulated blood vessel and nerve outgrowth, and improved healing of ischemic and diabetic wounds while decreasing TNF-alpha inflammatory cytokines.
BioMed Research International (2015)GHK-Cu reduced reactive oxygen species, increased antioxidant enzyme activity (including SOD via copper delivery), and suppressed inflammatory pathways — showing protective effects against bleomycin-induced lung injury models.
BioMed Research International (2015)Studies observed a 30–50% increase in hair follicle size with GHK-Cu treatment, along with stimulation of hair growth and increased follicle thickness in preclinical models.
International Journal of Molecular Sciences (2018)All findings above are sourced from peer-reviewed journals for educational reference. This product is for research purposes only — not for human consumption. Preclinical results may not translate to human outcomes.
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All products are for research and laboratory purposes only. Not intended for human or animal consumption. Only qualified professionals should handle these products.