TB-500
10mgVolume Pricing
Per unit — bulk discounts applied automaticallyWholesale pricing available for approved accounts
About TB-500
Thymosin Beta-4 fragment — a 43 amino acid synthetic peptide identical to the endogenous protein. Extensively researched for its role in cell migration, tissue repair, and angiogenesis studies.
Frequently Asked Questions
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Published Study Findings on TB-500
Detailed Research & Citations
In-depth findings from peer-reviewed preclinical and clinical studies
TB-500 is a synthetic peptide representing the active region of Thymosin Beta-4, a 43-amino acid protein involved in cell migration, tissue repair, and angiogenesis throughout the body.
Accelerated Wound Healing
Thymosin Beta-4 promoted re-epithelialization, cell migration, wound contraction, and collagen deposition in dermal and corneal wound models, including impaired healing contexts such as diabetic and aged mice.
Annals of the New York Academy of Sciences (2010)Reduced Scar Formation
Thymosin Beta-4 decreased myofibroblast presence in wound models, leading to reduced scar formation and fibrosis while maintaining effective tissue repair.
Annals of the New York Academy of Sciences (2010)Angiogenesis & Cell Migration
TB-500 promoted new blood vessel formation by increasing VEGF expression and mobilizing stem/progenitor cells through its actin-binding properties, facilitating tissue regeneration.
Nature (2004)NF-κB Downregulation
Thymosin Beta-4 reduced inflammation by downregulating NF-κB and decreasing levels of various inflammatory cytokines across brain, liver, eye, and heart disease models.
Expert Opinion on Biological Therapy (2020)Cardiac Protection & Repair
In chronic myocardial ischemia models, TB-500 reduced infarct size and improved contractile performance through anti-apoptotic (acute) and progenitor cell activation (chronic) mechanisms, promoting neovascularization.
Expert Opinion on Biological Therapy (2020)Neuroregeneration in Brain Injury
TB-500 promoted neurogenesis and angiogenesis while reducing brain lesion volume in traumatic brain injury models. In autoimmune encephalomyelitis models, it stimulated oligodendrogenesis and reduced inflammatory infiltrates.
Expert Opinion on Biological Therapy (2020)Phase I Human Safety Data
Phase I safety studies in healthy volunteers indicated Thymosin Beta-4 was well-tolerated without dose-limiting toxicities. A Phase II trial in severe dry eye showed both safety and symptom improvement.
Expert Opinion on Biological Therapy (2020)View All 3 Sources
- Thymosin β4: roles in development, repair, and engineering of the cardiovascular system
- Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
- Thymosin Beta 4: A Multi-Functional Regenerative Peptide — Basic Properties and Clinical Applications
All findings above are sourced from peer-reviewed journals for educational reference. This product is for research purposes only — not for human consumption. Preclinical results may not translate to human outcomes.
Chemical Identity
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