MK-677 (Ibutamoren)
12.5mgVolume Pricing
Per unit — bulk discounts applied automaticallyWholesale pricing available for approved accounts
About MK-677 (Ibutamoren)
A non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue. MK-677 is studied for its ability to stimulate the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) without significantly affecting cortisol levels.
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Published Study Findings on MK-677 (Ibutamoren)
Detailed Research & Citations
In-depth findings from peer-reviewed preclinical and clinical studies
MK-677 (Ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics the GH-stimulating action of the endogenous hormone ghrelin. It has been studied for its ability to increase lean body mass and bone mineral density.
Sustained Elevation of GH and IGF-1
MK-677 potently stimulates the ghrelin receptor, leading to a sustained, dose-dependent increase in serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) without significantly altering cortisol or prolactin levels.
Journal of Clinical Endocrinology & Metabolism (1998)Increase in Lean Body Mass
In clinical studies involving healthy older adults, once-daily administration of MK-677 over 12 months resulted in significant increases in lean body mass, likely driven by enhanced GH and IGF-1 signaling.
Annals of Internal Medicine (2008)Bone Turnover and Mineral Density
MK-677 administration increased markers of bone turnover in several studies, suggesting potential long-term benefits for bone mineral density and skeletal health in populations susceptible to bone loss.
Neuroendocrinology (1997)View All 3 Sources
- Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure
- Effects of an Oral Growth Hormone Secretagogue in Older Adults
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man
All findings above are sourced from peer-reviewed journals for educational reference. This product is for research purposes only — not for human consumption. Preclinical results may not translate to human outcomes.
Chemical Identity
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