Melanotan 2 (MT2)
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About Melanotan 2 (MT2)
A synthetic cyclic lactam analog of alpha-melanocyte-stimulating hormone (α-MSH). Melanotan II activates melanocortin receptors (MC1R–MC5R) and is extensively studied in dermatology and neuroendocrine research.
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Published Study Findings on Melanotan 2 (MT2)
Detailed Research & Citations
In-depth findings from peer-reviewed preclinical and clinical studies
Melanotan II is a synthetic cyclic lactam analog of α-melanocyte-stimulating hormone (α-MSH) that non-selectively activates melanocortin receptors MC1R through MC5R, studied across dermatology, metabolism, and neuroendocrine research.
Melanin Synthesis Stimulation
MT-II activated the MC1R receptor in melanocytes, increasing eumelanin synthesis and resulting in measurable skin darkening. A Phase I clinical study showed increased pigmentation after just five low doses in human subjects.
Clinical Pharmacology & Therapeutics (1996)UV Protection Research
By increasing eumelanin content in skin, MT-II was studied for its potential to provide enhanced protection against UV-induced DNA damage, with implications for photosensitivity disorders and vitiligo research.
Clinical Pharmacology & Therapeutics (1996)Appetite & Energy Regulation
Through MC3R and MC4R activation in the brain, MT-II suppressed appetite and affected feeding behavior in animal models. Chronic administration influenced energy homeostasis, thermogenesis, and lipid metabolism.
Peptides (2005)Insulin Sensitivity & Body Composition
Studies in mouse models showed MT-II increased insulin sensitivity of glucose disposal and reduced body mass without long-term caloric restriction, suggesting effects on metabolic parameters.
Diabetologia (2005)Melanoma Suppression (In Vivo)
A 2020 in vivo study demonstrated MT-II suppressed melanoma progression primarily by upregulating PTEN via MC1R, which inhibited AKT/NFκB signaling and downstream COX-2/PGE2 pathways.
Biomedicine & Pharmacotherapy (2020)View All 4 Sources
- Subcutaneous administration of a cyclic peptide analog of alpha-melanocyte-stimulating hormone in humans — Phase I trial
- Chronic effects of a melanocortin-4 receptor agonist (MT-II) on energy homeostasis in high-fat diet fed rats
- Melanotan II increases insulin sensitivity of glucose disposal in mice — a novel role for supraphysiological melanocortin receptor activation
- Melanotan-II suppresses the progression of melanomas through upregulation of PTEN via MC1R
All findings above are sourced from peer-reviewed journals for educational reference. This product is for research purposes only — not for human consumption. Preclinical results may not translate to human outcomes.
Chemical Identity
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